Haloperiodol

<1%, postmarketing, and/or case reports: Abnormal hepatic function tests, acneiform eruption, acute hepatic failure, agitation, agranulocytosis, akathisia, alopecia, amenorrhea, anaphylaxis, anemia, blurred vision, bronchopneumonia, bronchospasm, cardiac arrhythmia, cholestasis, cogwheel rigidity, confusion, decreased libido, depression, dizziness, dyskinesia, dysmenorrhea, dyspnea, edema, erectile dysfunction, exfoliative dermatitis, extrasystoles, facial edema, galactorrhea, gynecomastia, heatstroke, hepatic insufficiency, hepatitis, hyperammonemia, hyperhidrosis, hyperprolactinemia, hyperpyrexia, hypersensitivity angiitis, hypersensitivity reaction, hypertension, hyperthermia, hypoglycemia, hypokinesia, hypotension, hypothermia, injection site reaction, insomnia, jaundice, laryngeal edema, laryngospasm, leukocytosis, leukopenia, lymphocytosis with monocytosis, maculopapular rash, mask-like face, mastalgia, menorrhagia, motor dysfunction, muscle rigidity, muscle twitching, nausea, neonatal withdrawal, neuroleptic malignant syndrome, neutropenia, nystagmus, opisthotonus, orthostatic hypotension, pancytopenia, priapism, prolonged Q-T interval on ECG, pruritus, restlessness, rhabdomyolysis, sedation, seizure, SIADH, skin photosensitivity, skin rash, tachycardia, tardive dyskinesia, tardive dystonia, thrombocytopenia, torsades de pointes, torticollis, trismus, urinary retention, urticaria, ventricular arrhythmia, ventricular fibrillation, ventricular tachycardia, vomiting, weight gain, weight loss

The article states that haloperidol is "marginally effective." It cites a source that does not make this claim. In fact, any expert and many patients can tell you that this is not the case. Also, the article goes on to say that the citation "may be overly generous," which is a very subjective claim. Then it says that haloperidol "should only be used if other treatments are not a possibility" - this is also not specifically stated in the article, and is not consistent with the clinical opinion of most experts. I think it's unwise to be giving medical advice like this.

The influence of renal impairment on the pharmacokinetics of haloperidol has not been evaluated. About one-third of a haloperidol dose is excreted in urine, mostly as metabolites. Less than 3% of administered haloperidol is eliminated unchanged in the urine. Haloperidol metabolites are not considered to make a significant contribution to its activity, although for the reduced metabolite of haloperidol, back-conversion to haloperidol cannot be fully ruled out. Even though impairment of renal function is not expected to affect haloperidol elimination to a clinically relevant extent, caution is advised in patients with renal impairment, and especially those with severe impairment, due to the long half-life of haloperidol and its reduced metabolite, and the possibility of accumulation (see section ).

processing.... Drugs & Diseases haloperidol (Rx) Brand and Other Names: Haldol, Haldol Decanoate, more... Haloperidol LA, Peridol

  • Classes: Antipsychotics, 1st Generation
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Sections haloperidol (Rx)
  • Sections haloperidol
  • Dosing & Uses
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Dosing & Uses Adult Pediatric Geriatric Dosage Forms & Strengths tablet

An encephalopathic syndrome (characterized by weakness, lethargy , fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis , elevated serum enzymes, BUN , and fasting blood sugar) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL. A causal relationship between these events and the concomitant administration of lithium and HALDOL has not been established; however, patients receiving such combined therapy should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear.

Haloperiodol

haloperiodol

processing.... Drugs & Diseases haloperidol (Rx) Brand and Other Names: Haldol, Haldol Decanoate, more... Haloperidol LA, Peridol

  • Classes: Antipsychotics, 1st Generation
  • Share
  • Email
  • Print
  • Feedback
Close
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
Sections haloperidol (Rx)
  • Sections haloperidol
  • Dosing & Uses
  • Interactions
  • Adverse Effects
  • Warnings
  • Pregnancy
  • Pharmacology
  • Administration
  • Images
  • Patient Handout
  • Formulary
Dosing & Uses Adult Pediatric Geriatric Dosage Forms & Strengths tablet

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